The great donkey remark
” Congratulation Lorenzin and Siliquini (Italian superior health council)
di Giuseppe R,Brera
Dati inconfutabili mostrano il raddoppio del rischio da mortalità infantile (fino a 2,7 per il vaccino Hexavac) nel periodo successivo a vaccinazione esavalente ( dopo la prima dose). (dati 1999-2004) Dato che il lavoro è del 2011, come mai l’ex ministro Lorenzin e il Consiglio superiore della sanità diretto dalla prof. Siliquini non li hanno considerati prima della legge ?
I dati grezzi mostrano 52 decessi entro i 14 gg dalla vaccinazione
Risk period: 0–1 days | Risk period: 0–7 days | Risk period: 0–14 days | ||||
N | RR adj1 (95% CI) | N | RR adj1 (95% CI) | N | RR adj1 (95% CI) | |
All doses | 8 | 1.2 (0.4–2.1) | 34 | 1.3 (0.9–1.9) | 52 | 1.1 (0.8–1.5) |
1st dose | 5 | 1.2 (0.4–2.5) | 24 | 1.5 (1.0–2.3) | 34 | 1.2 (0.8–1.6) |
2nd – 3rd dose | 3 | 1.2 (0.3–3.0) | 10 | 1.0 (0.4–1.9) | 18 | 1.0 (0.6–1.6) |
Table 4
Vaccine groups | Risk period: 0–1 days | Risk period: 0–7 days | Risk period: 0–14 days | ||||||
N | P-d | RR adj1 (95% CI) | N | P-d | RR adj1 (95% CI) | N | P-d | RR adj1 (95% CI) | |
Any vaccine | 8 | 864 | 1.1 (0.5–2.4) | 34 | 3355 | 1.4 (0.9–2.1) | 52 | 6104 | 1.1 (0.8–1.6) |
All concomitant administration of six antigens | 7 | 593 | 1.5 (0.7–3.5) | 30 | 2276 | 1.8 (1.1–2.8) | 44 | 4112 | 1.5 (1.0–2.2) |
Hexavalent products2 | 4 | 322 | 1.5 (0.6–4.2) | 18 | 1231 | 2.0 (1.2–3.5) | 25 | 2228 | 1.5 (0.9–2.4) |
Hexavac | 1 | 160 | 0.7 (0.1–5.5) | 12 | 599 | 2.8 (1.4–5.3) | 13 | 1075 | 1.6 (0.8–3.1) |
Infanrix hexa | 3 | 160 | 2.3 (0.8–7.7) | 6 | 624 | 1.4 (0.6–3.1) | 12 | 1138 | 1.5 (0.8–2.7) |
Other concomitant administration of six antigens | 3 | 271 | 1.4 (0.4–4.8) | 12 | 1045 | 1.6 (0.8–3.0) | 19 | 1884 | 1.4 (0.8–2.3) |
Others | 1 | 271 | 0.5 (0.1–3.4) | 4 | 1079 | 0.5 (0.2–1.4) | 8 | 1978 | 0.6 (0.3–1.1) |
Control period | 192 | 29875 | 1 | 192 | 29875 | 1 | 192 | 29875 | 1 |
Table 5 30 Morti dopo la prima dose del vaccino con rischi tra 1,6 e 2,7
First dose | Second and third dose | |||||
N | P-d | RR adj1 (95% CI) | N | P-d | RR adj1 (95% CI) | |
Any administration of six antigens | 30 | 2457 | 1.9 (1.0–3.4) | 14 | 1655 | 1.2 (0.7–2.1) |
Hexavalent products 2 | 18 | 1263 | 2.2 (1.1–4.4) | 7 | 965 | 1.0 (0.5–2.1) |
Hexavac | 10 | 580 | 2.7 (1.1–6.9) | 3 | 480 | 0.8 (0.3–2.6) |
Infanrix hexa | 8 | 668 | 1.9 (0.8–4.2) | 4 | 485 | 1.1 (0.5–2.9) |
Other concomitant administration of six antigens | 12 | 1194 | 1.6 (0.8–3.2) | 7 | 690 | 1.4 (0.6–3.0) |
Control period | 192 | 29875 | 1 | 192 | 29875 | 1 |
dati dal lavoro
Sudden Unexpected Deaths and Vaccinations during the First Two Years of Life in Italy: A Case Series Study
Abstract
Background
The signal of an association between vaccination in the second year of life with a hexavalent vaccine and sudden unexpected deaths (SUD) in the two days following vaccination was reported in Germany in 2003. A study to establish whether the immunisation with hexavalent vaccines increased the short term risk of SUD in infants was conducted in Italy.
Methodology/Principal Findings
The reference population comprises around 3 million infants vaccinated in Italy in the study period 1999–2004 (1.5 million received hexavalent vaccines). Events of SUD in infants aged 1–23 months were identified through the death certificates. Vaccination history was retrieved from immunisation registries. Association between immunisation and death was assessed adopting a case series design focusing on the risk periods 0–1, 0–7, and 0–14 days after immunisation. Among the 604 infants who died of SUD, 244 (40%) had received at least one vaccination. Four deaths occurred within two days from vaccination with the hexavalent vaccines (RR = 1.5; 95% CI 0.6 to 4.2). The RRs for the risk periods 0–7 and 0–14 were 2.0 (95% CI 1.2 to 3.5) and 1.5 (95% CI 0.9 to 2.4). The increased risk was limited to the first dose (RR = 2.2; 95% CI 1.1 to 4.4), whereas no increase was observed for the second and third doses combined.
Conclusions
The RRs of SUD for any vaccines and any risk periods, even when greater than 1, were almost an order of magnitude lower than the estimates in Germany. The limited increase in RRs found in Italy appears confined to the first dose and may be partly explained by a residual uncontrolled confounding effect of age.